Uncovering the Signatures of Cellular Senescence in the Human Dorsolateral Prefrontal Cortex
Nick Sloan, Jason A. Mares, Aidan C. Daly, Lilian A. Coie, Shaunice Grier, Natalie Barretto, Obadele Casel, Kristy Kang, Chris Jackson, Maria Pedersen, Shruti Khiste, Benjamin T. Fullerton, Joana Petrescu, Courteney Mattison, Colin Smith, , Hemali P. Phatnani
The paper identifies senescent cell signatures in the human dorsolateral prefrontal cortex using spatial transcriptomics and single nucleus RNA sequencing, revealing heterogeneity and cell-type-specific aging patterns.
bioRxiv · Feb 19, 2025 · PreprintCell Biology