Revisiting p53:Sirt1 interaction in the light of controlling p53 acetylation levels
Vishnupriya Pandey, Frank Hause, Claudio Iacobucci, Christian H. Ihling, Christian Tueting, Panagiotis L. Kastritis, Christian Arlt, Andrea Sinz
This study presents the first structural model of the full-length p53:Sirt1 complex, showing Sirt1 selectively deacetylates p53 at K582 and binds acetylated p53 with a 1:1 stoichiometry.
Communications Chemistry · Jul 10, 2026Peer-reviewedBiochemistry