Discovery and optimization of a guanylhydrazone-based small molecule to replace bFGF for cell culture applications
Mikhail N. Feofanov, Gerrit M. Daubner, Andrea Saltalamacchia, Karsten Köhler, Christine Schulz, Clare Elizabeth Henry, Michael Josef Ziegler, Mohammed B. Benabderrahmane, Florence Andrée Suzanne Hiault, Tim-Michael Decker, Mei-Chun Shen, Jürgen Pahl, Sophie Lambertz, Hamid R. Noori
The paper identifies and optimizes a guanylhydrazone-based small molecule that mimics bFGF's function in cell culture, showing improved potency and thermal stability.
Biochemistry and Biophysics Reports · Jul 21, 2025Peer-reviewedBiochemistry