A freely accessible, adaptable hollow-fiber setup to reproduce first-order absorption: illustration with linezolid cerebrospinal fluid pharmacokinetic data
Noémie Prébonnaud, Alexia Chauzy, Nicolas Grégoire, Claire Dahyot‐Fizelier, Christophe Adier, Sandrine Marchand, Vincent Aranzana‐Climent
Splitting each dose into equal-amount continuous infusions of varying duration, computed by a new algorithm, lets a standard hollow-fiber model reproduce linezolid CSF pharmacokinetics within 20% of target parameters.
Microbiology Spectrum · May 15, 2025Peer-reviewedPharmacology & Toxicology✦ In-depth digest