Spatial patterning of fibroblast TGFβ signaling underlies treatment resistance in rheumatoid arthritis
Kartik Bhamidipati, Alexa B. R. McIntyre, Shideh Kazerounian, Ce Gao, Soon Wei Wong, Miles Tran, Sean A. Prell, Rachel Lau, Vikram Khedgikar, Christopher Altmann, Annabelle Small, Roopa Madhu, Sonia Presti, Ksenia S. Anufrieva, PHILIP E. BLAZAR, , Kevin Wei
Perivascular COMPhi fibrogenic fibroblasts expand in treatment-refractory rheumatoid arthritis synovium, where endothelial Notch signaling patterns fibroblast TGF-beta sensitivity via TGFBR3 regulation and persists despite post-treatment immune cell depletion.
Nature Immunology · Jan 15, 2026Peer-reviewedImmunology✦ In-depth digest