Author

Christopher P Denton

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 1 Systems Biology· 1

Signature Assays, Organisms & Methods

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Organism:human· 2 Assay:bulk RNA-seq· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:differential expression· 1 Approach:experimental assay· 1 Research Focus:gene regulatory network inference· 1 Assay:proteomics· 1 Approach:statistical model· 1

Frequent Co-Authors

Begoña Caballero-RuiziD· 1 shared Casey S Greene· 1 shared Christopher W WassoniD· 1 shared Emma Derrett-Smith· 1 shared Enrico De Lorenzis· 1 shared Eva M Clavane· 1 shared Francesco Del GaldoiD· 1 shared Harrison W Farber· 1 shared

Activity by Year

2016-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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1 shared paperImmunology

Begoña Caballero-RuizORCID

Mutual co-authors in cluster

Author profile →

2 papers

Recent·Most cited

Chloride intracellular channel 4 (CLIC4) is a global regulator of type 1 interferon signaling in Systemic Sclerosis (SSc) epithelial cells

Christopher W Wasson, Sophie L Dibb, Begoña Caballero-Ruiz, Eva M Clavane, Rebecca Wells, Vishal Kakkar, Enrico De Lorenzis, Rebecca L Ross, Jessica Bryon, Emma Derrett-Smith, Christopher P Denton, Paul J Meakin, Francesco Del Galdo

This study shows CLIC4 regulates type 1 interferon signaling in SSc epithelial cells and inhibiting it blocks IFN pathway activation.

bioRxiv · Mar 8, 2024 · PreprintImmunology

A Novel Multi-network Approach Reveals Tissue-specific Cellular Modulators of Fibrosis in Systemic Sclerosis, Pulmonary Fibrosis and Pulmonary Arterial Hypertension

Jaclyn N Taroni, Casey S Greene, Viktor Martyanov, Tammara A Wood, Romy Christmann, Harrison W Farber, Robert A Lafyatis, Christopher P Denton, Monique E Hinchcliff, Patricia A Pioli, J. Matthew Mahoney, Michael L Whitfield

The paper identifies a common immune-fibrotic gene expression signature across SSc, PF, and PAH and uses it to uncover tissue-specific cellular modulators of fibrosis.

bioRxiv · Jul 7, 2016Systems Biology