Candida glabrata replicating within macrophages experiences amino acid deprivation, DNA damage, and chromosome instability
Ariel Alejandro Aptekmann, Nathaly Cabrera, Melody C. Hayman, Ruth A. Watson, Joseph A. Stewart, Christopher Quinteros, Chang Liu, Caroline E Hayter, Mikhail V. Keniya, David S. Perlin, Juan Lucas Argueso, Erika Shor
This study shows that Candida glabrata replicating inside macrophages experiences amino acid deprivation, DNA damage, and chromosome instability, with mutations in RME1 enhancing its survival.
bioRxiv · Sep 15, 2025 · PreprintMicrobiology