Author

Christopher S Waters

University of California, San Francisco

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Systems Biology· 2

Signature Assays, Organisms & Methods

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Research Focus:differential expression· 1 Approach:experimental assay· 1 Organism:human· 1 Assay:proteomics· 1 Approach:statistical model· 1

Frequent Co-Authors

Lani F. WuiD· 2 shared Steven J. AltschuleriD· 2 shared Capria Rinaldi· 1 shared Karl KumbieriD· 1 shared Lee Rao· 1 shared Matthew P. JacobsoniD· 1 shared R. Jeremy NicholsiD· 1 shared Sigurd AngenentiD· 1 shared

Activity by Year

2022-2023 · peak 1/yr

Co-Author Collaboration Network

9 top collaborators · 30 mutual co-author links

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2 shared papersSystems Biology

Lani F. WuORCID

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2 papers

Recent·Most cited

Dissecting the effects of GTPase and kinase domain mutations on LRRK2 endosomal localization and activity

Capria Rinaldi, Christopher S Waters, Zizheng Li, Karl Kumbier, Lee Rao, R. Jeremy Nichols, Matthew P. Jacobson, Lani F. Wu, Steven J. Altschuler

The paper investigates how GTPase and kinase domain mutations in LRRK2 affect endosomal localization and Rab phosphorylation, finding that GTPase-inactivating mutants lead to more LRRK2+ endosomes and higher Rab phosphorylation.

Cell Reports · May 1, 2023Peer-reviewedSystems Biology

Commitment in the Pink1/Parkin mitophagy decision circuit

Christopher S Waters, Sigurd Angenent, Steven J. Altschuler, Lani F. Wu

The paper quantifies the relationship between PINK1 levels and Parkin recruitment dynamics to show a threshold and delay mechanism that prevents erroneous mitophagy activation.

bioRxiv · Oct 7, 2022 · PreprintSystems Biology