The function of human PIF1 in G quadruplex formation and replication stress response at ALT telomeres
Ashwin Ragupathi, Rongwei Zhao, Shakir Najit, Anthony Fernandez, Heba Zuhair Abid, Jiho Mo, Samantha Juang, Christopher Tong, Derin I. Yetil, Liam Buchanan, Connor McDowell, Lindsay Mosca, Bronwyn Kelly, Rebecca Kelly, Zakir Hossain, , Dong Zhang
This study investigates the role of human PIF1 in ALT telomere maintenance, showing its involvement in DNA damage, G4 formation, and replication stress response, with implications for cancer therapy.
bioRxiv · Sep 1, 2026 · PreprintMolecular Biology