HaloMPNN: retraining ProteinMPNN on halophilic proteomes for salt-tolerant enzyme design
Alyssa Lu Lee, Austin Seamann, Gwendolyn Chung, Clairie Zhao, Rohan Maddamsetti, Sagar D. Khare
This paper retrained ProteinMPNN on halophilic proteomes to design salt-tolerant enzymes, showing HaloMPNN shifts protein properties toward halophilic traits.
bioRxiv · Aug 4, 2026 · PreprintBioengineering