Scalable spatial DNA sequencing from archival tissue maps copy number subclones
Cristian Soitu, Ugur Sahin, Anette Magnussen, Ashley Wong, Willem Bonnaffé, Mengran Fan, Merve Bilici, Simon Davis, Román Fischer, Jasmine Reese, Toby House, Sorayya Moradi, Renuka Teague, Olaf Ansorge, Stefano Malacrino, , Srinivasa R. Rao
This paper introduces ARMS DNAseq, a scalable spatial genomic assay that maps copy number subclones in archival tissue, revealing tumor evolution and subclone associations with morphology and transcriptomic features.
bioRxiv · Aug 27, 2026 · PreprintGenomics