AMPK senses cellular levels of nicotinamide adenine dinucleotide
Niall Wilson, Yoana Rabanal‐Ruiz, Aniketh Bishnu, Shangze Xu, Congxin Sun, Mohd Syed Ahangar, Kevin M. Rattigan, Jiangyu Tang, Danyelle Silva-Amaral, Conchita Fraguas Bringas, Kei Sakamoto, Tetsushi Kataura, Sovan Sarkar, Elton Zeqiraj, G. Vignir Helgason, , Viktor I. Korolchuk
This study shows that AMPK senses NAD levels, with NAD binding to the gamma subunit and modulating AMPK activity, which affects metabolic pathways like mTORC1 and autophagy.
bioRxiv · May 21, 2026 · PreprintMolecular Biology