Constance A. Rich

Prevalence of errors in lab-made plasmids across the globe

The paper surveys lab-made plasmids globally and finds nearly half contain errors, with 40% of transfer plasmids having mutations in ITR regions due to instability.

A positional information gradient of sonic hedgehog is required for flight feather formation in avian wings

The paper shows that a Sonic hedgehog signaling gradient in chick embryos specifies flight feather patterns and identity through gene expression.

An intrinsic cell cycle timer terminates limb bud outgrowth

The paper shows that limb bud outgrowth termination is driven by an intrinsic cell cycle timer, not extrinsic signalling, and identifies a temporal switch in BMP signalling as a key regulator.