Targeted Delivery of Nucleic Acid and Protein Cargos into Primary Human Hematopoietic Stem Cells Using Bacteriophage T4
Chelsea E. Stamm, Jingen Zhu, Cory Davis-Vargas, Obaiah Dirasantha, Karthika Thankamani, Venigalla Basaveswara Rao
This paper develops a bacteriophage T4-based nanoparticle vector to deliver mRNA and protein payloads into primary human hematopoietic stem cells with up to 20% efficiency.
bioRxiv · Jan 29, 2026 · PreprintBioengineering