Phosphorylation of the Kv7.4 B helix reorganizes calmodulin interactions and reduces PIP2 binding
Phuc Phan, Courage Okose, Divya Sapkota, Willy Munyao, Dylan J. Girodat, Crystal R. Archer
This study shows phosphorylation of Thr552 in Kv7.4 reduces PIP2 binding and channel activity while reorganizing calmodulin interactions.
bioRxiv · Sep 22, 2026 · PreprintBiochemistry