Genome-scale base editing reveals the functional effects of variants in yeast
James Boocock, Lauren Crisman, Leslie A Alamo, Shivani Patel, Cindy Vo, Curtis Liu, Heriberto Marquez, Joshua S. Bloom, Leonid Kruglyak
This study uses genome-scale CRISPR base editing in yeast to assess the functional effects of 308,461 variants, identifying 18,009 with significant growth impacts.
bioRxiv · Oct 21, 2026 · PreprintGenetics