Cannabinoid CB2 receptor activation drives glucose uptake, shifting T cell metabolism.
Robert S. Leddy, Hannah M Phelan, Claire Connolly, Fabian Wehrmann, D Winter, Lorraine Brennan, David J O’Connell, Carol M. Aherne, Colm B. Collins
This paper shows that CB2R activation in T cells increases glucose uptake and shifts metabolism toward oxidative phosphorylation and the pentose phosphate pathway, with effects dependent on the receptor.
bioRxiv · Jul 10, 2026 · PreprintImmunology