Aβ-affine bifunctional copper chelators capable of Aβ-induced oxidative stress reduction and amyloid disaggregation
O. O. Krasnovskaya, D. Abramchuk, A. Vaneev, P. Gorelkin, M. Abakumov, R. Timoshenko, N. Chmelyuk, V. Vadehina, R. Kuanaeva, E. V. Dubrovin, V. Kolmogorov, E. K. Beloglazkina, A. S. Erofeev
This study demonstrates that Alz-5 reduces Aβ42-induced oxidative stress and amyloid aggregation in SH-SY5Y cells.
bioRxiv · Oct 10, 2023 · PreprintPharmacology & Toxicology