Intramembrane protease SPP defines a cholesterol-regulated abundance control of the mevalonate pathway enzyme SQS
D. Avci, R. Heidasch, M. Costa, C. Luechtenborg, D. Kale, B. Bruegger, M. K. Lemberg
The paper shows that SPP cleaves SQS at high cholesterol levels, targeting it for degradation via TRC8, thereby regulating mevalonate pathway abundance.
bioRxiv · Jul 19, 2021 · PreprintCell Biology