Identification of ERAD-dependent degrons for the endoplasmic reticulum lumen.
R. Sharninghausen, J. Hwang, D. Dennison, R. Baldridge
The paper identifies short linear sequences in the ER lumen that function as degrons, enabling proteasomal degradation via the ERAD system in yeast and mammalian cells.
bioRxiv · Jun 21, 2023Cell Biology