225Ac-labeled CD33-targeting antibody reverses resistance to Bcl-2 inhibitor venetoclax in acute myeloid leukemia models
R. Garg, K. J. Allen, W. Dawicki, E. M. Geoghegan, D. L. Ludwig, E. Dadachova
This study shows that combining 225Ac-lintuzumab with venetoclax enhances tumor cell killing and improves survival in venetoclax-resistant AML models by inducing DNA damage and reducing MCL-1 levels.
bioRxiv · Oct 9, 2020Cancer Biology