Comparative CNS Pharmacology of the Brutons Tyrosine Kinase (BTK) Inhibitor Tolebrutinib Versus Other BTK Inhibitor Candidates for Treating Multiple Sclerosis.
T. J. TURNER, P. Brun, R. Gruber, D. Ofengeim
This paper compares the CNS pharmacology of three BTK inhibitors in non-human primates, finding that tolebrutinib achieves higher CSF exposure than the others.
bioRxiv · Mar 25, 2024Pharmacology & Toxicology