Evolutionary adaptation of the folding pathway for secretability
D. Smets, A. Tsirigotaki, J. H. Smit, S. Krishnamurthy, A. Portaliou, A. Vorobieva, W. Vranken, S. Karamanou, A. Economou
This study identifies structural features that delay folding in secretory proteins, enabling their translocation, by comparing PpiA and PpiB.
bioRxiv · Apr 3, 2022 · PreprintBiochemistry