D. V. McLeod

A multilocus perspective on the evolutionary dynamicsof multistrain pathogens

The paper unifies existing models of multistrain pathogen evolution by identifying three key factors: immune protection strength, immunological dynamics, and antigen locus number.

Multilocus adaptation to vaccination

This study examines how vaccines influence the joint evolution of multiple mutations in pathogens, showing that vaccine types affect epistasis and recombination outcomes.

Mosaic vaccination: how distributing different vaccines across a population could improve epidemic control

This paper investigates mosaic vaccination, where different vaccines are distributed across a population, showing it can reduce infections and improve vaccine efficacy compared to uniform vaccination.

Epigenetic inheritance and the evolution of infectious diseases

This paper explores how epigenetic inheritance in pathogens affects virulence evolution and proposes epigenetic therapies targeting pathogen memory.

Understanding the evolution of multiple drug resistance in structured populations

This paper uses dynamical equations for linkage disequilibrium to analyze the evolution of multidrug resistance in structured populations and shows how they explain equilibrium patterns, transient dynamics, and drug prescription impacts.