In situ activation and heterologous production of a cryptic lantibiotic from a plant-ant derived Saccharopolyspora species
E. Vikeli, D. Widdick, S. F. Batey, D. Heine, N. A. Holmes, M. J. Bibb, D. J. Martins, N. E. Pierce, M. I. Hutchings, B. Wilkinson
This paper identifies and activates a cryptic lantibiotic gene cluster in a plant-ant associated Saccharopolyspora species, enabling the discovery of a novel antibiotic, kyamicin, and demonstrating a platform for heterologous production of lanthipeptides.
bioRxiv · Aug 13, 2019Microbiology