Human skin rejuvenation via mRNA
Li Li, Zhengkuan Tang, Xavier Portillo, Rohit Arora, Madeleine Yang, Esther Mintzer, Zhenrui Zhang, Stefano Sol, Fabiana Boncimino, Patrick Han, Michelle Z. Dion, Emery Di Cicco, D.D. Majewski, Asaf Ashkenazy-Titelman, Alexandru M. Pleşa, , George McDonald Church
This paper presents a single-cell atlas of skin aging and identifies ATF3 as a regulator of aging, leading to an mRNA-based treatment that reduces cell senescence and enhances skin rejuvenation.
Journal of Investigative Dermatology · Jul 21, 2026Peer-reviewedSynthetic Biology