Author

Da Xie

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Bioengineering· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Approach:deep learning· 1 Assay:DNA methylation· 1 Research Focus:drug response / drug discovery· 1 Research Focus:gene regulatory network inference· 1 Organism:human· 1 Organism:non-human primate· 1 Assay:whole-genome sequencing· 1

Frequent Co-Authors

Changrui FengiD· 2 shared Wendan ReniD· 2 shared Yuxuan WuiD· 2 shared Bin FuiD· 1 shared Chong-Ping Lai· 1 shared Dan LiangiD· 1 shared Dawei WangiD· 1 shared Erwei ZuoiD· 1 shared

Activity by Year

2025-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 33 mutual co-author links

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2 shared papersBioengineering

Changrui FengORCID

Mutual co-authors in cluster

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2 papers

Recent·Most cited

In vivo genome editing of human hematopoietic stem cells for treatment of blood disorders by mRNA delivery

Saijuan Xu, Dan Liang, Qiudao Wang, Yan Cheng, Da Xie, Gui Yang, Haokun Zhang, Changrui Feng, Feiyan Zhao, Wendan Ren, Gongrui Sun, Yang Yang, Lin Li, Yongrong Lai, Bin Fu, , Yuxuan Wu

This paper develops an antibody-free lipid nanoparticle system for in vivo mRNA delivery to human HSCs, enabling efficient base editing of HBG to treat blood disorders like beta-thalassemia and sickle cell disease.

Nature Biomedical Engineering · Aug 12, 2025Peer-reviewedBioengineering

Sequential Amino Acid Mutagenesis-Driven De Novo Evolution of Adenine Deaminases Enables Efficient In Vivo Base Editing in Primate

Jiaoyang Liao, Hongling Zhang, Shuanghong Chen, Shenlin Hsiao, Chong-Ping Lai, Feng Hu, Wendan Ren, Changrui Feng, Da Xie, Yanqiu Zheng, Wenhui Cai, Wenlong Wang, Yanhong Jiang, Dawei Wang, Erwei Zuo, , Yuming Lu

This paper develops hpABE5.20, a base editor with improved precision and reduced off-target effects through sequential amino acid mutagenesis and AI-based structural prediction.

bioRxiv · May 14, 2025 · PreprintBioengineering