The Streptococcus pyogenes M protein is involved in phenotypic resistance to phage A25 infection in presence of human serum.
Lionel Schiavolin, Jenny Steinmetz, Gwenaëlle Botquin, Valérie Delforge, Dalila Lakhloufi, Pierre R. Smeesters, Anne Botteaux
The paper shows that the M protein of S. pyogenes contributes to resistance against phage A25 infection in human serum by binding IgG and albumin, especially in the absence of fatty acids.
bioRxiv · Feb 7, 2024 · PreprintMicrobiology