Dan Wang

Genetic regulation of circulating metabolome in cattle

The paper presents a cattle metabolome atlas linking genetic variants to metabolites and traits, revealing colocalization with eQTL and causal gene-metabolite-trait networks.

A unified spatial transcriptome profiling of ten mouse organs

The paper presents a unified spatial transcriptomic dataset of 10 mouse organs, providing high-resolution expression matrices paired with histological images for method development and benchmarking.

Functional orthogonality of WRN inhibitor resistance enables alternating therapy and mutation-tolerant inhibitor design in MSI-H cancers

This study shows that resistance to different WRN inhibitors in MSI-H cancers creates orthogonal vulnerabilities, enabling alternating therapy and mutation-tolerant inhibitor design.

Apelin-13 in the paraventricular nucleus protects myocardium from ischemia via V1a receptor of the paraventricular nucleus and GABAA receptor γ2 of the nucleus tractus solitarii in rats

This study shows that apelin-13 overexpression in the paraventricular nucleus improves cardiac function in MI and I/R rats via V1a receptors and GABAA receptor γ2 in the nucleus tractus solitarii.

A second X chromosome improves cognition in aging male and female mice

The paper shows that a second X chromosome in aging mice improves cognition, with female gonads and sex chromosomes contributing to cognitive resilience.

Mycn regulates intestinal development through ribosomal biogenesis in a zebrafish model of Feingold syndrome 1

This study uses a zebrafish model of Feingold syndrome 1 to show that Mycn regulates intestinal development through ribosomal biogenesis and that leucine supplementation can rescue the intestinal defect.

Phylogenetic reconstruction and divergence time estimation of Blumea DC. (Asteraceae: Inuleae) in China based on nrDNA ITS and cpDNA trnL-F sequences

The paper reconstructs the phylogenetic relationships and estimates the divergence times of Blumea DC. in China using nrDNA ITS and cpDNA trnL-F sequences, finding monophyly and divergence during the Oligocene and Miocene.

Production of nonnatural straight chain amino acid 6-aminocaproate via an artificial recursive carbon-chain-extension cycle

The paper describes an engineered metabolic pathway in E. coli to produce nonnatural straight-chain amino acids via a recursive carbon-chain-extension cycle.

Age-dependent sexual dimorphism in the adult human gut microbiota

This study identifies age-related sex differences in gut microbiota composition and functionality across two population cohorts, showing women have more diverse and stable microbiota than men, with sex differences diminishing in older adults.

Molecular Detection of H.pylori Antibiotic-Resistant Genes and Bioinformatics Predictive Analysis

The paper analyzes antibiotic resistance mutations in H. pylori and predicts structural changes using bioinformatics tools.

Ennet: construction of potential cancer-driving networks based on somatic enhancer mutations only

Ennet identifies cancer-driving networks using somatic enhancer mutations, revealing known and novel networks across multiple cancer types.