Disentangling osteoarthritis-specific genetic effects from obesity to identify novel therapeutic targets
Chen‐Yang Su, Masashi Hasebe, Dandan Tan, Bangli Cao, Kevin Y. H. Liang, Takayoshi Sasako, Vincent Mooser, Wenmin Zhang, Sirui Zhou, Satoshi Yoshiji, Tianyuan Lu, Guillaume Butler‐Laporte
This study identifies OA-specific genetic effects and novel therapeutic targets by separating OA genetics from those shared with obesity using GWAS and proteomics data.
medRxiv · Sep 23, 2025 · PreprintGenetic & Genomic Medicine