Intracellular complement Factor B couples inflammatory sensing to metabolism, chromatin regulation and maladaptive tissue repair
Tilo Freiwald, Daniel Chauss, Md Tajmul, Jorge L. Trujillo-Ochoa, Dhaneshwar Kumar, Jianping Ma, Madeline Snyder, Nardos Cheru, Julius FE Jaeger, Yuxin Zhuang, Justin B. Gregor, Ganne Ganne, Luopin Wang, Yubing Guo, Maja Gunkel, , Behdad Afzali
The paper identifies an injury-induced complement program in kidney cells that couples inflammation to metabolism and chromatin regulation, promoting maladaptive fibrosis.
bioRxiv · Oct 11, 2026 · PreprintImmunology