Maternal-fetal immune conflict contributes to male-specific impairments in a mouse model of neurodevelopmental disorders
Irene Sanchez-Martin, Bharti Kukreja, Paige Henderson, Qianyu Lin, Daniel DiMartino, Valerie Bagan, Justin Park, Brian Thomas Kalish, Lucas Cheadle
A poly(I:C) dose at E12.5 causes placental junctional-zone breakdown, amniotic inflammation and developmental defects in a male-only subset of embryos within 24 hours, dependent on maternal IL-6.
Science Advances · Sep 16, 2026Peer-reviewedDevelopmental Biology✦ In-depth digest