A temporal threshold in TGF-β signaling separates reversible tissue adaptation from persistent NK cell effector dysfunction
Kevin Schmid, Christina Haimerl, Julia Stark, Erik Müller, Leon Merz, Robin P. Schenk, Karyna Pistrenko, Julia Baumgarten, Kim Berberich, Ulrike Bauer, Ursula Ehmer, Melanie Laschinger, Norbert Hüser, Daniel Hartmann, Jan P. Böttcher, , Gabriela Maria Wiedemann
This study shows that prolonged TGF-β signaling causes persistent NK cell dysfunction through epigenetic changes, while short-term signaling leads to reversible effects.
bioRxiv · Sep 25, 2026 · PreprintImmunology