Linker histone H1-0 is a specific mediator of the repressive ETV6::RUNX1 transcriptional landscape
Vera Helena Jepsen, Andrea Hänel, Daniel J. Picard, Rigveda Bhave, Rebecca Hasselmann, Juha Mehtonen, Julian Schliehe‐Diecks, Carla‐Johanna Kath, Vithusan Suppiyar, Yash Prasad, Katerina Schaal, Jia‐Wey Tu, Nadine Rüchel, Ersen Kameri, Nan Qin, , Ute Fischer
This study identifies H1-0 as a mediator of ETV6::RUNX1-induced quiescence in BCP-ALL preleukemic cells and suggests HDACi treatment as a potential therapeutic approach.
HemaSphere · Apr 1, 2025Peer-reviewedCancer Biology