Spatial Neuroimmune Crosstalk Driving Perineural Invasion in Head and Neck Squamous Cell Carcinoma
Riya Chhabra, Alfred Kao, Reena Ding, Suravi Bajaj, Symphony Griffith Jackson, Wei Tse Li, Daniel J. John, Jessica Wang‐Rodriguez, Weg M. Ongkeko
This study identifies a distinct nerve-proximal microenvironment in HNSCC associated with poor prognosis in HPV-negative tumors, highlighting a spatially organized tumor-nerve interaction.
bioRxiv · May 29, 2026 · PreprintCancer Biology