The SH3BGRL protein family nucleates and caps actin filaments via its conserved thioredoxin fold
Robin S. Heiringhoff, Daniel Marke, Ute Curth, Johannes N. Greve
This study identifies SH3BGRL proteins as non-enzymatic regulators of actin dynamics, promoting nucleation and inhibiting depolymerization through their thioredoxin fold structure.
bioRxiv · Mar 25, 2025 · PreprintBiochemistry