Patient-Derived Synovium-on-a-Chip Recapitulates Disease and Treatment Response and Permits Study of Resistance
Ruiqi Chen, Theresa Wampler Muskardin, Fanghao Shi, Yeji Lee, Christele Felix, Carolyn Harris, Lunan Liu, Eric Suh, Emily Wu, Scott Rodeo, David Mayman, Daniel Ramirez, Katsuo Kurabayashi, Timothy B. Niewold, Weiqiang Chen
This paper develops a patient-derived synovium-on-a-chip model to study RA disease and treatment response, finding that it correlates with clinical outcomes and identifies ECM signaling as a resistance mechanism.
bioRxiv · Nov 2, 2026 · PreprintBioengineering