Developmental Reactive Oxygen Species Target Histone Methylation to Individualize Stress resistance and Lifespan
Daphne Bazopoulou, Daniela Knoefler, Yongxin Zheng, Kathrin Ulrich, Bryndon J. Oleson, Lihan Xie, Minwook Kim, Anke Kaufmann, Young‐Tae Lee, Yali Dou, Yong Chen, Shu Quan, Ursula Jakob
The paper shows that early developmental ROS increases stress resistance and lifespan by reducing histone H3K4me3 levels in C. elegans and mammalian cells.
bioRxiv · Sep 5, 2019 · PreprintMolecular Biology