Two dynamic, N-terminal regions are required for function in Ribosomal RNA Adenine Dimethylase family members
Danielle A. McGaha, Alexandrea Collins, Luqman O. Ajisafe, Calvin C. Perdigao, Jordan L. Bondrowski, Karen Fetsch, Jack A. Dunkle
The paper identifies two N-terminal regions in RRAD enzymes critical for function, showing they promote rRNA binding and substrate positioning for methylation.
bioRxiv · Apr 19, 2024Biochemistry