A modular lentiviral system for multiplexed gene perturbation and functional analysis suggests interdependence of hormone receptors in breast cancer growth in vivo
Seher Alam, Daria Matvienko, Johan Boström, Maria Joao Almeida A Silva Pires, Aikaterini Papadimitropoulou, Saeed Eshtad, Kumar Sanjiv, Hong Qian, Nicholas C.K. Valerie, Cathrin Brisken, Mikael Altun
The paper introduces a modular lentiviral system for multiplexed gene perturbation and functional analysis, showing that ER+ breast cancer cells rely on AR, ER, and PR for in vivo growth.
bioRxiv · Oct 14, 2026 · PreprintMolecular Biology