Transposable element RNA dysregulation in mutant KRAS(G12C) 3D lung cancer spheroids
David Carrillo, Roman E. Reggiardo, John Lim, Gary L. Mantalas, Vikas Peddu, Daniel H. Kim
This study investigates how KRAS(G12C) mutations affect transposable element RNA expression in 3D lung cancer spheroids, finding mutation-specific TE RNA dysregulation and activation of Alu-derived RNAs with innate immunity genes.
bioRxiv · Feb 27, 2023 · PreprintGenomics