Author

David J. Ames

The University of Melbourne

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Genetics· 4 Neuroscience· 3 Genetic & Genomic Medicine· 2 Genomics· 1

Signature Assays, Organisms & Methods

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Organism:human· 10 Approach:statistical model· 10 Research Focus:GWAS / association mapping· 6 Assay:GWAS summary statistics· 5 Research Focus:differential expression· 3 Assay:bulk RNA-seq· 2 Assay:DNA methylation· 1 Research Focus:gene regulatory network inference· 1

Frequent Co-Authors

Nicola J. ArmstrongiD· 8 shared Michelle Luciano AiD· 7 shared Edith HoferiD· 6 shared Henry BrodatyiD· 6 shared Karen A. MatheriD· 6 shared Neda JahanshadiD· 6 shared Shuo LiiD· 6 shared Anbupalam ThalamuthuiD· 5 shared

Activity by Year

2017-2024 · peak 4/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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8 shared papersGenetics

Nicola J. ArmstrongORCID

Mutual co-authors in cluster

Author profile →

10 papers

Recent·Most cited

Genomic analysis of intracranial and subcortical brain volumes yields polygenic scores accounting for variation across ancestries

Luis M. García‐Marín, Adrián I. Campos, Santiago Díaz‐Torres, Jill A. Rabinowitz, Zuriel Ceja, Brittany L. Mitchell, Katrina L. Grasby, Jackson G. Thorp, Ingrid Agartz, Saud Alhusaini, David J. Ames, Philippe Amouyel, Ole A. Andreassen, Konstantinos Arfanakis, Alejandro Arias Vásquez, , Michelle Luciano A

The paper conducts GWAS on brain volumes, identifies genetic loci, and develops polygenic scores with cross-ancestry predictive ability and causal links to neuropsychiatric disorders.

Nature Genetics · Oct 21, 2024Peer-reviewedGenetic & Genomic Medicine

Comprehensive genetic analysis of the human lipidome identifies novel loci controlling lipid homeostasis with links to coronary artery disease

Gemma Cadby, Corey Giles, Phillip E. Melton, Kevin Huynh, Natalie A. Mellett, Thy Duong, Thu Anh Nguyen, Michelle A. Cinel, Alexander Smith, Gavriel Olshansky, Tingting Wang, Marta Brożyńska, Mike Inouye, Nina S. McCarthy, Amir Ariff, , Eric Keith Moses

This study identifies 667 genetic loci associated with lipid species and links 186 of them to coronary artery disease through integrative lipidomics and genomics.

Nature Communications · Jun 6, 2022Peer-reviewedGenetic & Genomic Medicine

Asymmetric thinning of the cerebral cortex across the adult lifespan is accelerated in Alzheimer's Disease

James M. Roe, Dídac Vidal-piñeiro A, Øystein Sørensen, Andreas M. Brandmaier, Sandra Düzel, Hector A. Gonzalez, Rogier Kievit, Ethan Knights, Simone Kühn, Ulman Lindenberger, Athanasia M. Mowinckel, Lars H Nyberg, Denise C. Park, Sara Pudas, Melissa M. Rundle, , Michael A. Vacher

The paper identifies asymmetric thinning of the cerebral cortex across aging and Alzheimer's Disease, showing that the initially thicker hemisphere thins faster, with this pattern replicated across multiple cohorts.

Nature Communications · Feb 1, 2021Peer-reviewedNeuroscience

Genetic and environmental determinants of variation in the plasma lipidome of older Australian twins

Matthew Wai Kin Wong, Anbupalam Thalamuthu, Nady Braidy, Karen A. Mather, Yue Liu, Liliana G Ciobanu, Bernhardt T. Baune, Nicola J. Armstrong, John B. Kwok, Peter R. Schofield, Margaret J. Wright, David J. Ames, Russell Pickford, Teresa Lee, Anne Poljak, Perminder Singh Sachdev

This study examines the heritability and environmental influences on the plasma lipidome in older Australian twins, finding most variation is due to unique environmental factors.

eLife · Jul 22, 2020Peer-reviewedGenetics

Epigenome-wide meta-analysis of blood DNA methylation and its association with subcortical volumes: findings from the ENIGMA Epigenetics Working Group

Tianye Jia, Congying Chu, Yun Liu, Jenny van Dongen, Evangelos Papastergios, Nicola J. Armstrong, Mark E. Bastin, Tania Carrillo‐Roa, Anouk den Braber, Mathew A. Harris, Rick Jansen, Jingyu Liu, Michelle Luciano A, Anil P. S. Ori, Roberto Roiz‐Santiáñez, , Sylvane Desrivières

The paper reports epigenome-wide meta-analyses of blood DNA methylation with subcortical brain volumes, identifying significant associations with hippocampal volume and potential biological mechanisms.

Molecular Psychiatry · Dec 6, 2019Peer-reviewedGenomics

Common genetic variation indicates separate etiologies for periventricular and deep white matter hyperintensities

Nicola J. Armstrong, Karen A. Mather, Muralidharan Sargurupremraj, Maria J. Knol, Rainer Malik, Claudia Liliana Satizábal, Lisa R. Yanek, Wen Wei, Vilmundur G. Gudnason, Nicole D Deuker, Lloyd T. Elliott, Edith Hofer, Neda Jahanshad, Shuo Li, Mark W. Logue, , Paul Nyquist

This study identifies genetic loci specific to periventricular and deep white matter hyperintensities, revealing distinct genetic architectures and potential biological mechanisms.

bioRxiv · Jun 27, 2019 · PreprintNeuroscience

Genetic Determinants of Cortical Structure (Thickness, Surface Area and Volumes) among Disease Free Adults in the CHARGE Consortium

Edith Hofer, Gennady V. Roshchupkin, Hieab H.H. Adams, Maria J. Knol, Honghuang Lin, Shuo Li, Habil Zare, Shahzad Ahmad, Nicola J. Armstrong, Claudia Liliana Satizábal, Manon Bernard, Joshua C. Bis, Nathan A. Gillespie, Michelle Luciano A, Aniket Mishra, , Marcio Almeida

The paper identifies 161 genome-wide significant genetic associations for cortical structure traits across 34 brain regions, highlighting key biological pathways and gene functions.

bioRxiv · Jun 19, 2019 · PreprintGenetics

Planar cell polarity pathway and development of the human visual cortex

Jean Shin, Shaojie Ma, Edith Hofer, Yash Patel, Gennady V. Roshchupkin, André M. M. Sousa, Xueqiu Jian, Rebecca Gottesman, Thomas H. Mosley, Myriam Fornage, Yasaman Saba, Lukas Pirpamer, Reinhold Schmidt, Helena Schmidt, Amaia Carrión-Castillo, , Shareefa Dalvie

The paper identifies genetic associations with cortical surface area using PCA and GWAS, linking DAAM1 to visual cortex development through mitochondrial pathways and thalamocortical input.

bioRxiv · Apr 25, 2019 · PreprintNeuroscience

Ninety-nine independent genetic loci influencing general cognitive function include genes associated with brain health and structure (N = 280,360)

Gail Davies, Max Lam, Sarah E. Harris, Joey W. Trampush, Michelle Luciano A, William David Hill, Saskia P. Hagenaars, Stuart James Ritchie, Riccardo Emilio Marioni, Chloe Fawns‐Ritchie, David C M Liewald, Judith A. Okely, Ari Ahola‐Olli, Catriona L. K. Barnes, Lars Bertram, , Luca Kleineidam

This study identifies 99 genetic loci associated with general cognitive function using data from 280,360 individuals, finding genes linked to brain structure and neurodegenerative disorders.

Nature Communications · May 22, 2018Peer-reviewedGenetics

Genetic Architecture of Subcortical Brain Structures in Over 40,000 Individuals Worldwide

Claudia Liliana Satizábal, Hieab H.H. Adams, Derrek P. Hibar, Charles C. White, Jason L. Stein, Markus R. Scholz, Muralidharan Sargurupremraj, Neda Jahanshad, Albert V. Smith, Joshua C. Bis, Xueqiu Jian, Michelle Luciano A, Edith Hofer, Alexander Teumer, Sven J. van der Lee, , Lachlan T. Strike

The paper identifies 25 genetic loci associated with subcortical brain structure volumes in over 40,000 individuals, revealing novel biology and potential drug targets.

bioRxiv · Aug 28, 2017 · PreprintGenetics