Multiplex programming of mappable, molecularly tagged genomic deletions
Aidan Keith, Riza M. Daza, Jonas Koeppel, Hanna Liao, David S. Lee, David K Moraes, Troy A. McDiarmid, Junhong Choi, Xiaoyi Li, Jean‐Benoît Lalanne, Chengxiang Qiu, Sudarshan Pinglay, Jay Shendure
The paper introduces OPTIMuS PRIME-Del, a CRISPR-based method for multiplexed, precise deletion of cis-regulatory elements, validated through molecular tagging and scRNA-seq analysis.
bioRxiv · Oct 17, 2026 · PreprintGenomics