Discovery and Structure Activity Relationship Optimization of a Novel Rv1625c Agonist Chemotype with Antitubercular Activity
Han Xie, Paridhi Sukheja, Kirsten Tolentino, Jasmine Webb, Ashley Woods, Victor Chi, Dipak Kathayat, Christine R. Montague, Brian C. VanderVen, Leonard L. Winneroski, Greg Durst, David Mendel, Philip A. Hipskind, Kenn Henry, Case W. McNamara, , Arnab K. Chatterjee
The paper identifies a novel Rv1625c agonist chemotype with antitubercular activity, optimizing its structure to improve potency and bioavailability.
bioRxiv · Sep 19, 2026 · PreprintMicrobiology