Phenome-wide association analysis of LDL-cholesterol lowering genetic variants in PCSK9
Amand Floriaan Schmidt, Michael Vaclav Holmes, David Preiss, Daniel I. Swerdlow, Spiros Denaxas, Ghazaleh Fatemifar, Rupert Faraway, Chris Finan, R Thomas Lumbers, Albert Henry, Dennis Valentine, Zammy Fairhurst-Hunter, Fernando Pires Hartwig, Bernardo Lessa Horta, Elina Hyppönen, , Albert Hofman D
The paper analyzes genetic variants at the PCSK9 locus to assess their phenotypic effects on lipid levels and disease outcomes, finding concordance with PCSK9 inhibitor trials for myocardial infarction but discordance for type 2 diabetes.
BMC Cardiovascular Disorders · Oct 29, 2019Peer-reviewedGenetics