Multiple bottlenecks constrain presentation of Mycobacterium tuberculosis antigens on MHC class I
Owen K. Leddy, Cal Gunnarsson, Patrick V. Holec, David Ren, Chiara Martello, Michael E. Birnbaum, Forest M. White, Bryan D. Bryson
The paper identifies bottlenecks in MHC-I antigen presentation by Mtb, showing that only a small fraction of predicted binders are actually presented, and develops computational models to improve prediction.
bioRxiv · Oct 22, 2026 · PreprintImmunology