Functional immune profiling reveals CD4+ T cell dysregulation associated with celiac disease
Anthony J. Farchione, HoChan Cheon, David Vremec, Julika Neumann, Gwenny M. P. J. Verstappen, Melinda Y. Hardy, Mai B. Margetts, Lauren J. Howson, Lee M. Henneken, Maureen Forde, Jason A. Tye–Din, Susanne Heinzel, Philip D. Hodgkin, Vanessa L. Bryant
The paper uses a novel assay and mathematical model to show CD4+ T cells from celiac disease patients have reduced proliferation and altered cytokine secretion compared to healthy donors.
bioRxiv · Jun 6, 2025 · PreprintImmunology