Immune-cell depleted diffuse large B-cell lymphomas have reduced expression of MHC class I
Kanutte Huse, Yngvild Nuvin Blaker, Jillian Wise, Marie Hairing Enemark, Maare Arffman, Ankush Sharma, Leo Meriranta, Sigve Nakken, Kathrine T. Isaksen, Ivana Spasevska, Vera I. Hilden, Chloé Beate Steen, David Warren, Bent Honoré, Klaus Beiske, , June H. Myklebust
The paper maps the tumor microenvironment in DLBCL using imaging mass cytometry and finds that immune-cell depleted tumors have reduced MHC-I expression and worse survival.
bioRxiv · Sep 3, 2026 · PreprintCancer Biology