Substance use disorders exhibit unique and disorder specific genetic associations with externalizing and internalizing psychopathology
Holly E. Poore, Maia Choi, David Zald, Denise A. Hien, COGA Collaborators, Peter B. Barr, Danielle M. Dick
This study identifies genetic relationships between substance use disorders and externalizing/internalizing psychopathology, finding that internalizing contributes uniquely to SUD risk.
medRxiv · Jan 22, 2026 · PreprintGenetic & Genomic Medicine