Perturbation biology models predict c-Myc as an effective co-target in RAF inhibitor resistant melanoma cells
Anil Korkut, Weiqing Wang, Emek Demir, Bülent Arman Aksoy, Xiaohong Jing, Evan Molinelli, Özgün Babur, Debra Bemis, David B. Solit, Christine Pratilas, Chris Sander
The paper uses perturbation biology to predict c-Myc as a co-target with BRAF/MEK inhibitors to overcome RAF inhibitor resistance in melanoma.
bioRxiv · Sep 11, 2014 · PreprintCancer Biology